Darren Hargrave Selected Research

Biomarkers (Surrogate Marker)

1/2022	Comprehensive analysis of the ErbB receptor family in pediatric nervous system tumors and rhabdomyosarcoma.
11/2019	A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.
1/2018	Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity.
1/2015	Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Darren Hargrave Research Topics

Disease

26	Neoplasms (Cancer) 01/2022 - 06/2002
22	Glioma (Gliomas) 01/2022 - 01/2009
10	Diffuse Intrinsic Pontine Glioma 01/2022 - 02/2008
7	Brain Neoplasms (Brain Tumor) 01/2021 - 01/2011
6	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 08/2009
6	Medulloblastoma 10/2017 - 09/2003
2	Ataxia (Dyssynergia) 01/2022 - 02/2013
2	Astrocytoma (Pilocytic Astrocytoma) 06/2021 - 09/2010
2	Vascular Malformations 11/2018 - 01/2018
2	Carcinogenesis 01/2018 - 01/2017
2	Melanoma (Melanoma, Malignant) 04/2017 - 06/2002
2	Body Weight (Weight, Body) 01/2017 - 09/2003
1	Plexiform Neurofibroma 11/2022
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 11/2022
1	Pituitary Diseases (Disease, Anterior Pituitary) 01/2022
1	Nervous System Neoplasms (Neoplasms, Nervous System) 01/2022
1	Rhabdomyosarcoma 01/2022
1	Alcoholism (Alcohol Abuse) 11/2021
1	Disease Progression 01/2021
1	Neurofibromatoses (Neurofibromatosis) 01/2021
1	Arthralgia (Joint Pain) 12/2019
1	Exanthema (Rash) 12/2019
1	Thrombocytopenia (Thrombopenia) 01/2015
1	Neutropenia 01/2015
1	Anemia 01/2015
1	Neuroblastoma 01/2011
1	Clinical Deterioration 09/2010
1	Oligodendroglioma 09/2009
1	Gliosarcoma 09/2009
1	Primitive Neuroectodermal Tumors (PNET) 09/2003
1	Weight Loss (Weight Reduction) 09/2003
1	Weight Gain 09/2003

Drug/Important Bio-Agent (IBA)

11	Pharmaceutical PreparationsIBA 11/2021 - 01/2009
10	dipinacoline glutamateIBA 01/2022 - 02/2008
5	Biological ProductsIBA 01/2018 - 01/2009
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2009
4	Temozolomide (Temodar)FDA LinkGeneric 01/2018 - 11/2010
3	ErbB Receptors (EGF Receptor)IBA 01/2022 - 09/2009
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2022 - 04/2017
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 11/2010
2	Bevacizumab (Avastin)FDA Link 01/2019 - 01/2018
2	1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA 01/2017 - 01/2015
2	Histones (Histone)IBA 05/2016 - 05/2013
2	Irinotecan (Camptosar)FDA LinkGeneric 09/2013 - 05/2013
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2011 - 09/2009
1	AZD 6244IBA 11/2022
1	Amino Acids FDA Link 01/2022
1	Epidermal Growth Factor (EGF)IBA 01/2022
1	human ERBB2 proteinIBA 01/2022
1	Disulfiram (Antabuse)FDA Link 11/2021
1	GadoliniumIBA 06/2021
1	Contrast MediaIBA 06/2021
1	Cell-Free Nucleic AcidsIBA 01/2021
1	Circulating Tumor DNAIBA 01/2021
1	dabrafenibIBA 12/2019
1	InflammasomesIBA 01/2018
1	Mitogen-Activated Protein KinasesIBA 01/2018
1	sonidegibIBA 10/2017
1	trametinibIBA 04/2017
1	ChromatinIBA 01/2017
1	Aurora KinasesIBA 01/2015
1	Aurora Kinase AIBA 01/2015
1	fluoroethylcholineIBA 01/2015
1	Choline (Choline Chloride)IBA 01/2015
1	Vinblastine (Vinblastine Sulfate)FDA Link 04/2012
1	TensinsIBA 01/2011
1	Antineoplastic Agents (Antineoplastics)IBA 01/2011
1	Phosphates (Orthophosphate)IBA 01/2011
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2010
1	MethyltransferasesIBA 11/2010
1	Tamoxifen FDA LinkGeneric 10/2010
1	Vincristine (Oncovin)FDA LinkGeneric 09/2010
1	Carboplatin (JM8)FDA LinkGeneric 09/2010
1	ParaffinIBA 07/2010
1	Formaldehyde (Formol)FDA Link 07/2010
1	Platelet-Derived Growth Factor alpha ReceptorIBA 06/2010
1	Phosphotransferases (Kinase)IBA 09/2009
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 09/2009
1	epidermal growth factor receptor VIIIIBA 09/2009
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2009
1	Imatinib Mesylate (Gleevec)FDA Link 09/2009
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 06/2002

Therapy/Procedure

16	Therapeutics 11/2022 - 01/2009
9	Radiotherapy 01/2022 - 09/2003
5	Drug Therapy (Chemotherapy) 10/2020 - 09/2003
2	Re-Irradiation 01/2022 - 01/2017
1	Proton Therapy 01/2021
1	Operative Surgical Procedures 01/2021
1	Immunotherapy 01/2020
1	Duration of Therapy 12/2019
1	Precision Medicine 11/2019
1	Time-to-Treatment 05/2013
1	Investigational Therapies (Experimental Therapy) 01/2011
1	Cranial Irradiation 06/2010
1	Enteral Nutrition (Feeding, Tube) 09/2003
1	Parenteral Nutrition 09/2003